This will vary from client to client based on their skin condition and level of skin damage, as well as the amount of attention and therapy that is necessary to restore the skin to its healthy condition. It is however valuable to mention that most clients start to notice a change in their skin after two to three weeks. It is also important to note that more drastic results can be seen if the optiphi® Skin Rejuvenation Treatment is combined with the use of optiphi® homecare products